p19arf cell signaling Search Results


p19arf  (Cell Signaling Technology Inc)
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Cell Signaling Technology Inc p19arf
( A ) V5 and IgG CUT&RUN tracks at the Il3ra , Bcl2 , and Myc loci in Cdkn2a -KO MYB::PLEKHO1 leukemia cells. ( B ) TPM of Il3ra (CD123), Bcl2 , Myc , Ncam1 (CD56), Nrp1 (BDCA4), and Irf4 in Hoxb8-FL cell–derived pDCs ( n = 8) and Hoxb8-FL cell–derived leukemias of the indicated genotypes ( n = 4 per genotype). ( C ) Growth curves of Hoxb8-FL.MS5 cells transduced with V5-MYB constructs of the indicated genotypes. ( D ) Western blots showing p16INK4A and <t>p19ARF</t> expression in Hoxb8-FL.MS5 cells of the indicated genotypes. ( E ) Cell cycle analysis of Hoxb8-FL.MS5 cells. (Left) Representative flow plots of the indicated genotypes. (Right) Quantification of cells in each cell cycle phase as a proportion of total cells ( n = 4 per genotype). Significance tests compare proportion of cells in G1. ( A and E ) Data represent mean ± SEM. Significance determined by 1-way ANOVA with Tukey correction for multiple comparisons. * P <0.05, ** P <0.01, *** P < 0.001.
P19arf, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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( A ) V5 and IgG CUT&RUN tracks at the Il3ra , Bcl2 , and Myc loci in Cdkn2a -KO MYB::PLEKHO1 leukemia cells. ( B ) TPM of Il3ra (CD123), Bcl2 , Myc , Ncam1 (CD56), Nrp1 (BDCA4), and Irf4 in Hoxb8-FL cell–derived pDCs ( n = 8) and Hoxb8-FL cell–derived leukemias of the indicated genotypes ( n = 4 per genotype). ( C ) Growth curves of Hoxb8-FL.MS5 cells transduced with V5-MYB constructs of the indicated genotypes. ( D ) Western blots showing p16INK4A and p19ARF expression in Hoxb8-FL.MS5 cells of the indicated genotypes. ( E ) Cell cycle analysis of Hoxb8-FL.MS5 cells. (Left) Representative flow plots of the indicated genotypes. (Right) Quantification of cells in each cell cycle phase as a proportion of total cells ( n = 4 per genotype). Significance tests compare proportion of cells in G1. ( A and E ) Data represent mean ± SEM. Significance determined by 1-way ANOVA with Tukey correction for multiple comparisons. * P <0.05, ** P <0.01, *** P < 0.001.

Journal: JCI Insight

Article Title: BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia

doi: 10.1172/jci.insight.183889

Figure Lengend Snippet: ( A ) V5 and IgG CUT&RUN tracks at the Il3ra , Bcl2 , and Myc loci in Cdkn2a -KO MYB::PLEKHO1 leukemia cells. ( B ) TPM of Il3ra (CD123), Bcl2 , Myc , Ncam1 (CD56), Nrp1 (BDCA4), and Irf4 in Hoxb8-FL cell–derived pDCs ( n = 8) and Hoxb8-FL cell–derived leukemias of the indicated genotypes ( n = 4 per genotype). ( C ) Growth curves of Hoxb8-FL.MS5 cells transduced with V5-MYB constructs of the indicated genotypes. ( D ) Western blots showing p16INK4A and p19ARF expression in Hoxb8-FL.MS5 cells of the indicated genotypes. ( E ) Cell cycle analysis of Hoxb8-FL.MS5 cells. (Left) Representative flow plots of the indicated genotypes. (Right) Quantification of cells in each cell cycle phase as a proportion of total cells ( n = 4 per genotype). Significance tests compare proportion of cells in G1. ( A and E ) Data represent mean ± SEM. Significance determined by 1-way ANOVA with Tukey correction for multiple comparisons. * P <0.05, ** P <0.01, *** P < 0.001.

Article Snippet: Antibodies used for Western blots were: MYB (Abcam, ab45150), V5 (Cell Signaling Technology, 13202), ACTB (Santa Cruz Biotechnology Inc., sc-47778), GAPDH (Cell Signaling Technology, 2118), p16INK4A (Cell Signaling Technology, 29271), and p19ARF (Cell Signaling Technology, 77184).

Techniques: Derivative Assay, Transduction, Construct, Western Blot, Expressing, Cell Cycle Assay